In his first Budget he put 4p on a pint of beer,
14p on a bottle of wine
and 55p on a bottle of spirits.
Duty on a packet of cigarettes is up 11p.
He announced a one-off £950 tax on the most polluting new cars
but put a 2p rise in fuel duty back six months.
Mr Darling, who insisted the UK could "weather economic storms", also increased winter fuel payments.
"The cost of living is going up and Labour is making it worse," added Mr Cameron.
Liberal Democrat leader Nick Clegg said Mr Darling could have helped "the millions of hard pressed families who are feeling the pinch".
But instead he had delivered a "meagre tinkering budget which gives precious little help to the poor but maintains special treatment to the rich".
There were no further U-turns on capital gains tax or non-domiciled residents in Mr Darling's Budget statement.
But he was forced to cut his forecasts for economic growth for this year by 0.25% - to between 1.75% and 2.25% - and he announced a big increase in government borrowing, which is set to go up by £14bn over the next two years.
There will also be an increase in the overall tax burden over the next three years.