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ALC-0315
Signal word Warning
Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statement(s)
P264 Wash hands thoroughly after handling
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: Wash with plenty of soap and water.
P337+P313 If eye irritation persists: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing
This information is based on our current knowledge. However the chemical, physical, and toxicological properties have not been
completely investigated.
The above information is correct to the best of our present knowledge but does not purport to
be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must
only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of
safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from
handling or from contact with this produc
Caution: Product has not been fully validated for medical applications. For research use only.
https://assets.publishing.service.g...162b2__UKPAR___PFIZER_BIONTECH__15Dec2020.pdf
This report is based on the information provided by the company
In addition to BNT162b2 RNA this product also
contains
the excipients
ALC
-
0315 =
(
4
-
hydroxybutyl)
azanediyl)bis
(hexane
-
6,1
-
diyl)bis
(2
-
hexyldecanoate
),
ALC
-
0159 =
2
Uridine is replaced by modified N1
-
methylpseudouridine (
m1
ΨTP)
in the
RNA synthesis
which
increases RNA persistence
in
-
vivo
through
dampening of innate immune response to itself
.
Novel excipients
ALC
-
0315 is a cationic lipid and is critical to the self
-
assembly process of the particle itself,
the ability
of the particle to be taken up into cells and the escape of the RNA from the
endosome. ALC
-
0159
is a po
lyethylene glycol (PEG) lipid conjugate (i
.
e
.
PEGylated lipid).
-
[(
polyethylene glycol)
-
2000]
-
N
,N
-
ditetradecylacetamide, 1,2
-
Distearoyl
-
sn
-
glycero
-
3
phosphocholine
,
cholesterol,
potassium chloride, pota
ssium di
hydrogen phosphate, sodium
chloride, disodium hydrogen phosphate dihydrate, sucrose and water for injections.
https://assets.publishing.service.g...162b2__UKPAR___PFIZER_BIONTECH__15Dec2020.pdf
https://www.technologyreview.com/20...ingredients-of-pfizers-el bichito-19-vaccine/