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Platelet factor 4 - Wikipedia
Clinical significance
The heparin
F4 complex is the antigen in heparin-induced thrombocytopenia (HIT), an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin.[9] PF4 autoantibodies have also been found in patients with thrombosis and antiestéticatures resembling HIT but no prior administration of heparin.[10] Antibodies against PF4 have been implicated in cases of thrombosis and thrombocytopenia subsequent to vaccination with the Oxford–AstraZeneca or the Janssen el bichito-19 vaccine.[11][12] This phenomenon has been termed vaccine-induced immune thrombotic thrombocytopenia (VITT).[13] Changes in the expression of PF4 have also been associated with symptoms of long el bichito.[14]It is increased in patients with systemic sclerosis that also have interstitial lung disease.[15]
The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole.[16]
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