JuanJoseRuiz
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Just 2% of SARS-CoV-2−positive individuals carry 90% of the bichito circulating in communities
View ORCID ProfileQing Yang, Tassa K. Saldi, Patrick K. Gonzales, Erika Lasda, View ORCID ProfileCarolyn J. Decker, Kimngan L. Tat, View ORCID ProfileMorgan R. Fink, Cole R. Hager, View ORCID ProfileJack C. Davis, Christopher D. Ozeroff, Denise Muhlrad, Stephen K. Clark, Will T. Fattor, Nicholas R. Meyerson, View ORCID ProfileCamille L. Paige, Alison R. Gilchrist, View ORCID ProfileArturo Barbachano-Guerrero, Emma R. Worden-Sapper, Sharon S. Wu, Gloria R. Brisson, Matthew B. McQueen, Robin D. Dowell, View ORCID ProfileLeslie Leinwand, View ORCID ProfileRoy Parker, and View ORCID ProfileSara L. Sawyer
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PNAS May 25, 2021 118 (21) e2104547118; Just 2% of SARS-CoV-2−positive individuals carry 90% of the bichito circulating in communities
Significance
We analyzed data from saliva-based el bichito-19 screening deployed on the University of Colorado Boulder campus. Our dataset is unique in that all SARS-CoV-2−positive individuals reported no symptoms at the time of saliva collection, and therefore were infected but asymptomatic or presymptomatic. We found that 1) the distribution of viral loads observed in our asymptomatic college population was indistinguishable from what has been reported in hospitalized populations; 2) regardless of symptomatic status, approximately 50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the infection; and 3) just 2% of infected individuals carry 90% of the virions circulating within communities, serving as viral “supercarriers” and likely also superspreaders.
Abstract
We analyze data from the fall 2020 pandemic response efforts at the University of Colorado Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory syndrome cobi19 2 (SARS-CoV-2) using qRT-PCR. All samples were collected from individuals who reported no symptoms associated with el bichito-19 on the day of collection. From these, 1,405 positive cases were identified. The distribution of viral loads within these asymptomatic individuals was indistinguishable from what has been previously observed in symptomatic individuals. Regardless of symptomatic status, ∼50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the disease, based on having low viral loads in a range from which live bichito has rarely been isolated. We find that, at any given time, just 2% of individuals carry 90% of the virions circulating within communities, serving as viral “supercarriers” and possibly also superspreaders.
View ORCID ProfileQing Yang, Tassa K. Saldi, Patrick K. Gonzales, Erika Lasda, View ORCID ProfileCarolyn J. Decker, Kimngan L. Tat, View ORCID ProfileMorgan R. Fink, Cole R. Hager, View ORCID ProfileJack C. Davis, Christopher D. Ozeroff, Denise Muhlrad, Stephen K. Clark, Will T. Fattor, Nicholas R. Meyerson, View ORCID ProfileCamille L. Paige, Alison R. Gilchrist, View ORCID ProfileArturo Barbachano-Guerrero, Emma R. Worden-Sapper, Sharon S. Wu, Gloria R. Brisson, Matthew B. McQueen, Robin D. Dowell, View ORCID ProfileLeslie Leinwand, View ORCID ProfileRoy Parker, and View ORCID ProfileSara L. Sawyer
See all authors and affiliations
PNAS May 25, 2021 118 (21) e2104547118; Just 2% of SARS-CoV-2−positive individuals carry 90% of the bichito circulating in communities
- Edited by Peter Palese, Icahn School of Medicine at Mount Sinai, New York, NY, and approved April 11, 2021 (received for review March 8, 2021)
Significance
We analyzed data from saliva-based el bichito-19 screening deployed on the University of Colorado Boulder campus. Our dataset is unique in that all SARS-CoV-2−positive individuals reported no symptoms at the time of saliva collection, and therefore were infected but asymptomatic or presymptomatic. We found that 1) the distribution of viral loads observed in our asymptomatic college population was indistinguishable from what has been reported in hospitalized populations; 2) regardless of symptomatic status, approximately 50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the infection; and 3) just 2% of infected individuals carry 90% of the virions circulating within communities, serving as viral “supercarriers” and likely also superspreaders.
Abstract
We analyze data from the fall 2020 pandemic response efforts at the University of Colorado Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory syndrome cobi19 2 (SARS-CoV-2) using qRT-PCR. All samples were collected from individuals who reported no symptoms associated with el bichito-19 on the day of collection. From these, 1,405 positive cases were identified. The distribution of viral loads within these asymptomatic individuals was indistinguishable from what has been previously observed in symptomatic individuals. Regardless of symptomatic status, ∼50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the disease, based on having low viral loads in a range from which live bichito has rarely been isolated. We find that, at any given time, just 2% of individuals carry 90% of the virions circulating within communities, serving as viral “supercarriers” and possibly also superspreaders.
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